St Mary's Church, Rotherhithe, is the local Church of England parish church in Rotherhithe, formerly in Surrey and now part of south east London. The parish is now within the diocese of Southwark and under the jurisdiction of the Bishop of Fulham. The 18th-century church is in St Marychurch Street and is dedicated to Mary, mother of Jesus, and it is particularly proud of its connections with the Pilgrim Fathers. It remains a living and working church, supported by local people and serving a broad community.

Rotherhithe is a district of South London, England, and part of the London Borough of Southwark. It is on a peninsula on the south bank of the Thames, facing Wapping, Shadwell and Limehouse on the north bank, with the Isle of Dogs to the east. It borders Bermondsey to the west and Deptford to the south-east. The district is a part of the Docklands area.