St Mary's Hospital is an NHS hospital in Paddington, in the City of Westminster, London, founded in 1845. Since the UK's first academic health science centre was created in 2008, it has been operated by Imperial College Healthcare NHS Trust, which also operates Charing Cross Hospital, Hammersmith Hospital, Queen Charlotte's and Chelsea Hospital and the Western Eye Hospital.

Paddington is an area in the City of Westminster, in central London, England. A medieval parish then a metropolitan borough, it was integrated with Westminster and Greater London in 1965. Paddington station, designed by the engineer Isambard Kingdom Brunel opened in 1847. It is also the site of St Mary's Hospital and the former Paddington Green Police Station.