St Paul's Church, Shadwell, is a Grade II* listed Church of England church, located between The Highway and Shadwell Basin, on the edge of Wapping, in the East End of London, England. The church has had varying fortunes over many centuries, and is now very active, having been supported recently by Holy Trinity Brompton Church.

The Highway, part of which was formerly known as the Ratcliffe Highway, is a road in the London Borough of Tower Hamlets, in the East End of London. The route dates back to Roman times. In the 19th century it had a reputation for vice and crime and was the location of the Ratcliff Highway murders. Prior to a renaming programme of 1937, different parts of the route had different names depending on what district they were in.