The Stafford and Uttoxeter Railway was authorised by Act of Parliament on 29 July 1862, to build a line between the towns of Stafford and Uttoxeter in Staffordshire, England. It opened for traffic in 1867. It opened on 23 December 1867. Construction cost had much exceeded estimates, and income was poor, so that the company was always in financial difficulty. It was placed in receivership in 1875. The Great Northern Railway (GNR) had running powers to Uttoxeter and was persuaded to acquire the company, which it did in 1881. The GNR spent a considerable sum on improving the line, but it never made money and it was closed to passengers on 4 December 1939. Goods traffic ceased in 1951, except for a short stub to RAF Stafford; this too closed in 1975.

Stafford is a market town and the county town of Staffordshire, England. It is located about 15 miles (24 km) south of Stoke-on-Trent, 15 miles (24 km) north of Wolverhampton, and 24 miles (39 km) northwest of Birmingham. The town had a population of 71,673 in 2021, and is the main settlement within the larger Borough of Stafford, which had a population of 136,837 in 2021.