Brigadier-General Stand Watie, also known as Standhope Uwatie and Isaac S. Watie, was a Cherokee politician who served as the second principal chief of the Cherokee Nation from 1862 to 1866. The Cherokee Nation allied with the Confederate States during the American Civil War, and he was subsequently the only Native American Confederate general officer. Watie commanded Indian forces in the Trans-Mississippi Theater, made up mostly of Cherokee, Muskogee, and Seminole. He was the last Confederate States Army general to surrender.

The general officers of the Confederate States Army (CSA) were the senior military leaders of the Confederate States of America during the American Civil War of 1861–1865. They were often former officers from the United States Army before the Civil War, while others were given the rank based on merit or when necessity demanded. Most Confederate generals needed confirmation from the Confederate States Congress, much like prospective generals in the modern U.S. armed forces.