Stanley Lloyd Miller was an American chemist who made important experiments concerning the origin of life by demonstrating that a wide range of vital organic compounds can be synthesized by fairly simple chemical processes from inorganic substances. In 1952 he performed the Miller–Urey experiment, which showed that complex organic molecules could be synthesised from inorganic precursors. The experiment was widely reported, and provided evidence for the idea that the chemical evolution of the early Earth had caused the natural synthesis of organic compounds from inanimate inorganic molecules.

In biology, abiogenesis, or the origin of life, is the natural process by which life has arisen from non-living matter, such as simple organic compounds. The prevailing scientific hypothesis is that the transition from non-living to living entities on Earth was not a single event, but a process of increasing complexity involving the formation of a habitable planet, the prebiotic synthesis of organic molecules, molecular self-replication, self-assembly, autocatalysis, and the emergence of cell membranes. The transition from non-life to life has never been observed experimentally, but many proposals have been made for different stages of the process.