Ste. Genevieve is a city in Ste. Genevieve Township and is the county seat of Ste. Genevieve County, Missouri, United States. The population was 4,999 at the 2020 census. Founded in 1735 by French Canadian colonists and settlers from east of the river, it was the first organized European settlement west of the Mississippi River in present-day Missouri. Today, it is home to Ste. Genevieve National Historical Park, the 422nd unit of the National Park Service.

René-Auguste Chouteau Jr., also known as Auguste Chouteau, was the founder of St. Louis, Missouri, a successful fur trader and a politician. He and his partner had a monopoly for many years of fur trade with the large Osage tribe on the Missouri River. He had numerous business interests in St. Louis and was well-connected with the various rulers: French, Spanish, and American.