In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can change into various types of cells and proliferate indefinitely to produce more of the same stem
Transmission electron micrograph of a mesenchymal stem cell displaying typical ultrastructural characteristics
Mouse embryonic stem cells with fluorescent marker
Human embryonic stem cell colony on mouse embryonic fibroblast feeder layer
Induced pluripotent stem cells are a type of pluripotent stem cell that can be generated directly from a somatic cell. The iPSC technology was pioneered by Shinya Yamanaka and Kazutoshi Takahashi in K
Stem cell
…cell therapy. In 2006, a Japanese team led by Shinya Yamanaka discovered a method to convert mature body cells back into stem cells. These were termed induced pluripotent stem cells (iPSCs). The term stem cell was coined by Theodor Boveri and Valentin Haecker in the late 19th century. Pioneering works in theory of blood stem cell…
Confocal microscopic image of a colony of human induced pluripotent stem cells derived from a patient with oculocutaneous albinism. Blue indicates transcription factor Oct-4, green the protein SSEA4, and red the nuclei of the cells.