The Stepford Cuckoos are a set of fictional mutants, psychically linked quintuplets appearing in American comic books published by Marvel Comics. The alphabetical order of the Cuckoos' first names corresponds with their ages, with Celeste being the firstborn and Sophie being the youngest. Originally calling themselves the Five-in-One, after the deaths of Esme and Sophie the remaining sisters were known as the Three-in-One. They are commonly associated with the Xavier Institute for Higher Learning and successor mutant schools.

The Gifted is an American superhero television series created for Fox by Matt Nix, based on Marvel Comics' X-Men properties, set in an alternate timeline to the X-Men film series where the X-Men have disappeared. The show is produced by 20th Century Fox Television in association with Marvel Television, with Nix serving as showrunner.