"Stewie Kills Lois" and "Lois Kills Stewie" is a two-part episode of the sixth season of the animated comedy series Family Guy, which was originally produced for the end of the fifth season. Respectively, both parts are the fourth and fifth episode of their season, and they premiered in the United States on Fox on November 4 and 11, 2007. In the former, housewife Lois receives cruise tickets as a birthday present from anthropomorphic dog Brian, and invites her husband, Peter, on the cruise with her. This upsets Stewie, and he ultimately appears to murder Lois while she is on the cruise, only to find out that she had survived the attack as the year passes. In the latter, Lois is able to expose Stewie as the villain that he is, but he soon accomplishes his dream of world domination.

Lois Patrice Griffin is a fictional character from the animated television series Family Guy. She is voiced by Alex Borstein and first appeared on television, along with the rest of the Griffin family, in the episode "Death Has a Shadow" on January 31, 1999. Lois was originally created and designed by series creator Seth MacFarlane for a student film called The Life of Larry in 1995.