Stoddard County is a county located in the southeastern portion of the U.S. state of Missouri. As of the 2020 census, the population was 28,672. The county seat is Bloomfield. The county was officially organized on January 2, 1835, and is named for Amos Stoddard, the first American commandant of Upper Louisiana.

Amos Stoddard was a career United States Army officer who served in both the American Revolutionary War and the War of 1812, in which he was mortally wounded.