Stoke Mandeville is a village and civil parish in the Vale of Aylesbury in Buckinghamshire, England. It is located three miles (4.9 km) from Aylesbury and 3.4 miles (5.5 km) from the market town of Wendover. Although a separate civil parish, the village falls within the Aylesbury Urban Area. According to the Census Report the area of this parish is 1,460 acres (5.9 km2).

Stoke Mandeville Hospital is a large National Health Service (NHS) hospital located on the parish borders of Aylesbury and Stoke Mandeville, Buckinghamshire, England. It is managed by Buckinghamshire Healthcare NHS Trust.