Stopping power is the ability of a weapon – typically a ranged weapon such as a firearm – to cause a target to be incapacitated or immobilized. Stopping power contrasts with lethality in that it pertains only to a weapon's ability to make the target cease action, regardless of whether or not death ultimately occurs. Which ammunition cartridges have the greatest stopping power is a much-debated topic.

A cartridge, also known as a round, is a type of pre-assembled firearm ammunition packaging a projectile, a propellant substance and an ignition device (primer) within a metallic, paper, or plastic case that is precisely made to fit within the barrel chamber of a breechloading gun, for convenient transportation and handling during shooting. Although in popular usage the term "bullet" is often used to refer to a complete cartridge, the correct usage only refers to the projectile.