Stoystown is a borough in Somerset County, Pennsylvania, United States. It is part of the Johnstown, Pennsylvania, Metropolitan Statistical Area. The population was 300 at the 2020 census. Stoystown is located south-southeast of Johnstown and northeast of Somerset.

U.S. Route 30 (US 30) is a U.S. Highway that runs east–west across the southern part of Pennsylvania, passing through Pittsburgh and Philadelphia on its way from the West Virginia state line east to the Benjamin Franklin Bridge over the Delaware River into New Jersey.