The Straits of Florida, Florida Straits, or Florida Strait is a strait located south-southeast of the North American mainland, generally accepted to be between the Gulf of Mexico and the Atlantic Ocean, and between the Florida Keys (U.S.) and Cuba. It is 93 mi (150 km) wide at the narrowest point between Key West and the Cuban shore, and has been sounded to a depth of 6,000 feet (1,800 m). The strait carries the Florida Current, the beginning of the Gulf Stream, from the Gulf of Mexico.

The Gulf of Mexico is an ocean basin and a marginal sea of the Atlantic Ocean, mostly surrounded by the North American continent. It is bounded on the northeast, north and northwest by the Gulf Coast of the United States; on the southwest and south by the Mexican states of Tamaulipas, Veracruz, Tabasco, Campeche, Yucatán, and Quintana Roo; and on the southeast by Cuba. The Southern U.S. states of Texas, Louisiana, Mississippi, Alabama, and Florida, which border the gulf on the north, are often referred to as the "Third Coast" of the United States.