Strikeforce: Henderson vs. Babalu II, was a mixed martial arts event that was held by Strikeforce on December 4, 2010 at the Scottrade Center in St Louis, Missouri, United States.

The Enterprise Center is an 18,096-seat arena located in downtown St. Louis, Missouri, United States. Its primary tenant is the St. Louis Blues of the National Hockey League, but it is also used for other functions, such as NCAA basketball, NCAA hockey, concerts, professional wrestling and more. In a typical year, the facility hosts about 175 events. Industry trade publication Pollstar has previously ranked Enterprise Center among the top ten arenas worldwide in tickets sold to non-team events, but the facility has since fallen into the upper sixties, as of 2017.