In mathematics and chemistry, a space group is the symmetry group of a configuration in space in three dimensions. In three dimensions, there are 230 if chiral copies are considered distinct. Space groups are studied in dimensions other than 3 where they are sometimes called Bieberbach groups, are discrete cocompact groups of isometries of an oriented Euclidean space. In crystallography, space groups are called the crystallographic or Fedorov groups, represent a description of the symmetry of the crystal. A definitive source regarding 3-dimensional space groups is the International Tables for Crystallography. Space groups in 2 dimensions are the 17 wallpaper groups which have been known for several centuries, though the proof that the list was complete was only given in 1891, after the much more difficult classification of space groups had been completed. In 1879 Leonhard Sohncke listed the 65 space groups. More he listed 66 groups, but Fedorov and Schönflies both noticed that two of them were the same.
The space groups in three dimensions were first enumerated by Fedorov, shortly afterwards were independently enumerated by Schönflies. The correct list of 230 space groups was found by 1892 during correspondence between Fedorov and Schönflies. Barlow enumerated the groups with a different method, but omitted four groups though he had the correct list of 230 groups from Fedorov and Schönflies. Burckhardt describes the history of the discovery of the space groups in detail; the space groups in three dimensions are made from combinations of the 32 crystallographic point groups with the 14 Bravais lattices, each of the latter belonging to one of 7 lattice systems. This results in a space group being some combination of the translational symmetry of a unit cell including lattice centering, the point group symmetry operations of reflection and improper rotation, the screw axis and glide plane symmetry operations; the combination of all these symmetry operations results in a total of 230 different space groups describing all possible crystal symmetries.
The elements of the space group fixing a point of space are the identity element, reflections and improper rotations. The translations form a normal abelian subgroup of rank 3, called the Bravais lattice. There are 14 possible types of Bravais lattice; the quotient of the space group by the Bravais lattice is a finite group, one of the 32 possible point groups. Translation is defined as the face moves from one point to another point. A glide plane is a reflection in a plane, followed by a translation parallel with that plane; this is noted depending on which axis the glide is along. There is the n glide, a glide along the half of a diagonal of a face, the d glide, a fourth of the way along either a face or space diagonal of the unit cell; the latter is called the diamond glide plane. In 17 space groups, due to the centering of the cell, the glides occur in two perpendicular directions i.e. the same glide plane can be called b or c, a or b, a or c. For example, group Abm2 could be called Acm2, group Ccca could be called Cccb.
In 1992, it was suggested to use symbol e for such planes. The symbols for five space groups have been modified: A screw axis is a rotation about an axis, followed by a translation along the direction of the axis; these are noted by a number, n, to describe the degree of rotation, where the number is how many operations must be applied to complete a full rotation. The degree of translation is added as a subscript showing how far along the axis the translation is, as a portion of the parallel lattice vector. So, 21 is a twofold rotation followed by a translation of 1/2 of the lattice vector; the general formula for the action of an element of a space group is y = M.x + D where M is its matrix, D is its vector, where the element transforms point x into point y. In general, D = D + D, where D is a unique function of M, zero for M being the identity; the matrices M form a point group, a basis of the space group. The lattice dimension can be less than the overall dimension, resulting in a "subperiodic" space group.
For:: One-dimensional line groups: Two-dimensional line groups: frieze groups: Wallpaper groups: Three-dimensional line groups. Some of these methods can assign several different names to the same space group, so altogether there are many thousands of different names. Number; the International Union of Crystallography publishes tables of all space group types, assigns each a unique number from 1 to 230. The numbering is arbitrary, except that groups with the same crystal system or point group are given consecutive numbers. International symbol or Hermann–Mauguin notation; the Hermann–Mauguin notation describes the lattice and some generators for the group. It has a shortened form called the international short symbol, the one most used in crystallography
Proteus is a genus of Gram-negative Proteobacteria. Proteus bacilli are distributed in nature as saprophytes, being found in decomposing animal matter, manure soil, the mammalian intestine, human and animal feces, they are opportunistic pathogens responsible for urinary and septic infections nosocomial. Three species—P. Vulgaris, P. mirabilis, P. penneri—are opportunistic human pathogens. Proteus includes pathogens responsible for many human urinary tract infections. P. mirabilis causes wound and urinary tract infections. Most strains of P. mirabilis are sensitive to ampicillin and cephalosporins. P. vulgaris is not sensitive to these antibiotics. However, this organism is isolated less in the laboratory and only targets immunosuppressed individuals. P. vulgaris occurs in the intestines of humans and a wide variety of animals, in manure and polluted waters. P. mirabilis, once attached to the urinary tract, infects the kidney more than E. coli. P. mirabilis is found as a free-living organism in soil and water.
About 10–15% of kidney stones are struvite stones, caused by alkalinization of the urine by the action of the urease enzyme of Proteus bacterial species. Proteus species do not ferment lactose, but have shown to be capable glucose fermenters depending on the species in a triple sugar iron test. Since it belongs to the family Enterobacteriaceae, general characters are applied on this genus, it is catalase - and nitrate-positive. Specific tests include positive phenylalanine deaminase tests. On the species level, indole is considered reliable, as it is positive for P. vulgaris, but negative for P. mirabilis. Most strains produce a powerful urease enzyme, which hydrolyzes urea to ammonia and carbon monoxide. Species can be motile, have characteristic "swarming" patterns. Underlying these behaviors are the somatic O and flagellar H antigens, so named based on Kauffman–White classification; this system is based on historic observations of Edmund Weil and Arthur Felix of a thin surface film produced by agar-grown flagellated Proteus strains, a film that resembled the mist produced by breath on a glass.
Flagellated variants were therefore designated H forms. The cell wall O-antigen of certain strains of Proteus, such as OX-2, OX-19, OX-k, crossreact with several species of Rickettsiae; these Proteus antigens can be used in laboratory to detect the presence of antibodies against certain Rickettsiae members in patient's serum. This test is called Weil-Felix reaction after its originators. Dienes phenomenon
Germany the Federal Republic of Germany, is a country in Central and Western Europe, lying between the Baltic and North Seas to the north, the Alps to the south. It borders Denmark to the north and the Czech Republic to the east and Switzerland to the south, France to the southwest, Luxembourg and the Netherlands to the west. Germany includes 16 constituent states, covers an area of 357,386 square kilometres, has a temperate seasonal climate. With 83 million inhabitants, it is the second most populous state of Europe after Russia, the most populous state lying in Europe, as well as the most populous member state of the European Union. Germany is a decentralized country, its capital and largest metropolis is Berlin, while Frankfurt serves as its financial capital and has the country's busiest airport. Germany's largest urban area is the Ruhr, with its main centres of Essen; the country's other major cities are Hamburg, Cologne, Stuttgart, Düsseldorf, Dresden, Bremen and Nuremberg. Various Germanic tribes have inhabited the northern parts of modern Germany since classical antiquity.
A region named Germania was documented before 100 AD. During the Migration Period, the Germanic tribes expanded southward. Beginning in the 10th century, German territories formed a central part of the Holy Roman Empire. During the 16th century, northern German regions became the centre of the Protestant Reformation. After the collapse of the Holy Roman Empire, the German Confederation was formed in 1815; the German revolutions of 1848–49 resulted in the Frankfurt Parliament establishing major democratic rights. In 1871, Germany became a nation state when most of the German states unified into the Prussian-dominated German Empire. After World War I and the revolution of 1918–19, the Empire was replaced by the parliamentary Weimar Republic; the Nazi seizure of power in 1933 led to the establishment of a dictatorship, the annexation of Austria, World War II, the Holocaust. After the end of World War II in Europe and a period of Allied occupation, Austria was re-established as an independent country and two new German states were founded: West Germany, formed from the American and French occupation zones, East Germany, formed from the Soviet occupation zone.
Following the Revolutions of 1989 that ended communist rule in Central and Eastern Europe, the country was reunified on 3 October 1990. Today, the sovereign state of Germany is a federal parliamentary republic led by a chancellor, it is a great power with a strong economy. As a global leader in several industrial and technological sectors, it is both the world's third-largest exporter and importer of goods; as a developed country with a high standard of living, it upholds a social security and universal health care system, environmental protection, a tuition-free university education. The Federal Republic of Germany was a founding member of the European Economic Community in 1957 and the European Union in 1993, it is part of the Schengen Area and became a co-founder of the Eurozone in 1999. Germany is a member of the United Nations, NATO, the G7, the G20, the OECD. Known for its rich cultural history, Germany has been continuously the home of influential and successful artists, musicians, film people, entrepreneurs, scientists and inventors.
Germany has a large number of World Heritage sites and is among the top tourism destinations in the world. The English word Germany derives from the Latin Germania, which came into use after Julius Caesar adopted it for the peoples east of the Rhine; the German term Deutschland diutisciu land is derived from deutsch, descended from Old High German diutisc "popular" used to distinguish the language of the common people from Latin and its Romance descendants. This in turn descends from Proto-Germanic *þiudiskaz "popular", derived from *þeudō, descended from Proto-Indo-European *tewtéh₂- "people", from which the word Teutons originates; the discovery of the Mauer 1 mandible shows that ancient humans were present in Germany at least 600,000 years ago. The oldest complete hunting weapons found anywhere in the world were discovered in a coal mine in Schöningen between 1994 and 1998 where eight 380,000-year-old wooden javelins of 1.82 to 2.25 m length were unearthed. The Neander Valley was the location where the first non-modern human fossil was discovered.
The Neanderthal 1 fossils are known to be 40,000 years old. Evidence of modern humans dated, has been found in caves in the Swabian Jura near Ulm; the finds included 42,000-year-old bird bone and mammoth ivory flutes which are the oldest musical instruments found, the 40,000-year-old Ice Age Lion Man, the oldest uncontested figurative art discovered, the 35,000-year-old Venus of Hohle Fels, the oldest uncontested human figurative art discovered. The Nebra sky disk is a bronze artefact created during the European Bronze Age attributed to a site near Nebra, Saxony-Anhalt, it is part of UNESCO's Memory of the World Programme. The Germanic tribes are thought to date from the Pre-Roman Iron Age. From southern Scandinavia and north Germany, they expanded south and west from the 1st century BC, coming into contact with the Celtic tribes of Gaul as well
In the history of Europe, the Middle Ages lasted from the 5th to the 15th century. It began with the fall of the Western Roman Empire and merged into the Renaissance and the Age of Discovery; the Middle Ages is the middle period of the three traditional divisions of Western history: classical antiquity, the medieval period, the modern period. The medieval period is itself subdivided into the Early and Late Middle Ages. Population decline, counterurbanisation, collapse of centralized authority and mass migrations of tribes, which had begun in Late Antiquity, continued in the Early Middle Ages; the large-scale movements of the Migration Period, including various Germanic peoples, formed new kingdoms in what remained of the Western Roman Empire. In the 7th century, North Africa and the Middle East—once part of the Byzantine Empire—came under the rule of the Umayyad Caliphate, an Islamic empire, after conquest by Muhammad's successors. Although there were substantial changes in society and political structures, the break with classical antiquity was not complete.
The still-sizeable Byzantine Empire, Rome's direct continuation, survived in the Eastern Mediterranean and remained a major power. The empire's law code, the Corpus Juris Civilis or "Code of Justinian", was rediscovered in Northern Italy in 1070 and became admired in the Middle Ages. In the West, most kingdoms incorporated the few extant Roman institutions. Monasteries were founded; the Franks, under the Carolingian dynasty established the Carolingian Empire during the 8th and early 9th century. It covered much of Western Europe but succumbed to the pressures of internal civil wars combined with external invasions: Vikings from the north, Magyars from the east, Saracens from the south. During the High Middle Ages, which began after 1000, the population of Europe increased as technological and agricultural innovations allowed trade to flourish and the Medieval Warm Period climate change allowed crop yields to increase. Manorialism, the organisation of peasants into villages that owed rent and labour services to the nobles, feudalism, the political structure whereby knights and lower-status nobles owed military service to their overlords in return for the right to rent from lands and manors, were two of the ways society was organised in the High Middle Ages.
The Crusades, first preached in 1095, were military attempts by Western European Christians to regain control of the Holy Land from Muslims. Kings became the heads of centralised nation-states, reducing crime and violence but making the ideal of a unified Christendom more distant. Intellectual life was marked by scholasticism, a philosophy that emphasised joining faith to reason, by the founding of universities; the theology of Thomas Aquinas, the paintings of Giotto, the poetry of Dante and Chaucer, the travels of Marco Polo, the Gothic architecture of cathedrals such as Chartres are among the outstanding achievements toward the end of this period and into the Late Middle Ages. The Late Middle Ages was marked by difficulties and calamities including famine and war, which diminished the population of Europe. Controversy and the Western Schism within the Catholic Church paralleled the interstate conflict, civil strife, peasant revolts that occurred in the kingdoms. Cultural and technological developments transformed European society, concluding the Late Middle Ages and beginning the early modern period.
The Middle Ages is one of the three major periods in the most enduring scheme for analysing European history: classical civilisation, or Antiquity. The "Middle Ages" first appears in Latin in 1469 as media tempestas or "middle season". In early usage, there were many variants, including medium aevum, or "middle age", first recorded in 1604, media saecula, or "middle ages", first recorded in 1625; the alternative term "medieval" derives from medium aevum. Medieval writers divided history into periods such as the "Six Ages" or the "Four Empires", considered their time to be the last before the end of the world; when referring to their own times, they spoke of them as being "modern". In the 1330s, the humanist and poet Petrarch referred to pre-Christian times as antiqua and to the Christian period as nova. Leonardo Bruni was the first historian to use tripartite periodisation in his History of the Florentine People, with a middle period "between the fall of the Roman Empire and the revival of city life sometime in late eleventh and twelfth centuries".
Tripartite periodisation became standard after the 17th-century German historian Christoph Cellarius divided history into three periods: ancient and modern. The most given starting point for the Middle Ages is around 500, with the date of 476 first used by Bruni. Starting dates are sometimes used in the outer parts of Europe. For Europe as a whole, 1500 is considered to be the end of the Middle Ages, but there is no universally agreed upon end date. Depending on the context, events such as the conquest of Constantinople by the Turks in 1453, Christopher Columbus's first voyage to the Americas in 1492, or the Protestant Reformation in 1517 are sometimes used. English historians use the Battle of Bosworth Field in 1485 to mark the end of the period. For Spain, dates used are the death of King Ferdinand II in 1516, the death of Queen Isabella I of Castile in 1504, or the conquest of Granada in 1492. Historians from Romance-speaking countries tend to divide the Middle Ages into two parts: an earlier "High" and late
In optics, the refractive index or index of refraction of a material is a dimensionless number that describes how fast light propagates through the material. It is defined as n = c v, where c is the speed of light in vacuum and v is the phase velocity of light in the medium. For example, the refractive index of water is 1.333, meaning that light travels 1.333 times as fast in vacuum as in water. The refractive index determines how much the path of light is bent, or refracted, when entering a material; this is described by Snell's law of refraction, n1 sinθ1 = n2 sinθ2, where θ1 and θ2 are the angles of incidence and refraction of a ray crossing the interface between two media with refractive indices n1 and n2. The refractive indices determine the amount of light, reflected when reaching the interface, as well as the critical angle for total internal reflection and Brewster's angle; the refractive index can be seen as the factor by which the speed and the wavelength of the radiation are reduced with respect to their vacuum values: the speed of light in a medium is v = c/n, the wavelength in that medium is λ = λ0/n, where λ0 is the wavelength of that light in vacuum.
This implies that vacuum has a refractive index of 1, that the frequency of the wave is not affected by the refractive index. As a result, the energy of the photon, therefore the perceived color of the refracted light to a human eye which depends on photon energy, is not affected by the refraction or the refractive index of the medium. While the refractive index affects wavelength, it depends on photon frequency and energy so the resulting difference in the bending angle causes white light to split into its constituent colors; this is called dispersion. It can be observed in prisms and rainbows, chromatic aberration in lenses. Light propagation in absorbing materials can be described using a complex-valued refractive index; the imaginary part handles the attenuation, while the real part accounts for refraction. The concept of refractive index applies within the full electromagnetic spectrum, from X-rays to radio waves, it can be applied to wave phenomena such as sound. In this case the speed of sound is used instead of that of light, a reference medium other than vacuum must be chosen.
The refractive index n of an optical medium is defined as the ratio of the speed of light in vacuum, c = 299792458 m/s, the phase velocity v of light in the medium, n = c v. The phase velocity is the speed at which the crests or the phase of the wave moves, which may be different from the group velocity, the speed at which the pulse of light or the envelope of the wave moves; the definition above is sometimes referred to as the absolute refractive index or the absolute index of refraction to distinguish it from definitions where the speed of light in other reference media than vacuum is used. Air at a standardized pressure and temperature has been common as a reference medium. Thomas Young was the person who first used, invented, the name "index of refraction", in 1807. At the same time he changed this value of refractive power into a single number, instead of the traditional ratio of two numbers; the ratio had the disadvantage of different appearances. Newton, who called it the "proportion of the sines of incidence and refraction", wrote it as a ratio of two numbers, like "529 to 396".
Hauksbee, who called it the "ratio of refraction", wrote it as a ratio with a fixed numerator, like "10000 to 7451.9". Hutton wrote it as a ratio with a fixed denominator, like 1.3358 to 1. Young did not use a symbol for the index of refraction, in 1807. In the next years, others started using different symbols: n, m, µ; the symbol n prevailed. For visible light most transparent media have refractive indices between 1 and 2. A few examples are given in the adjacent table; these values are measured at the yellow doublet D-line of sodium, with a wavelength of 589 nanometers, as is conventionally done. Gases at atmospheric pressure have refractive indices close to 1 because of their low density. All solids and liquids have refractive indices above 1.3, with aerogel as the clear exception. Aerogel is a low density solid that can be produced with refractive index in the range from 1.002 to 1.265. Moissanite lies at the other end of the range with a refractive index as high as 2.65. Most plastics have refractive indices in the range from 1.3 to 1.7, but some high-refractive-index polymers can have values as high as 1.76.
For infrared light refractive indices can be higher. Germanium is transparent in the wavelength region from 2 to 14 µm and has a refractive index of about 4. A type of new materials, called topological insulator, was found holding higher refractive index of up to 6 in near to mid infrared frequency range. Moreover, topological insulator material are transparent; these excellent properties make them a type of significant materials for infrared optics. According to the theory of relativity, no information can travel faster than the speed of light in vacuum, but this does not mean that the refractive index cannot be lower than 1; the refractive index measures the phase velocity of light. The phase velocity is the speed at which the crests of the wave move and can be faster than the speed of light in vacuum, thereby give a refractive index below 1; this can occur close to resonance frequencies, for absorbing media, in plasmas, for X-rays. In the X-ray regime the refractive indices are
The streak of a mineral is the color of the powder produced when it is dragged across an un-weathered surface. Unlike the apparent color of a mineral, which for most minerals can vary the trail of finely ground powder has a more consistent characteristic color, is thus an important diagnostic tool in mineral identification. If no streak seems to be made, the mineral's streak is said to be colorless. Streak is important as a diagnostic for opaque and colored materials, it is less useful for silicate minerals, most of which have a white streak or are too hard to powder easily. The apparent color of a mineral can vary because of trace impurities or a disturbed macroscopic crystal structure. Small amounts of an impurity that absorbs a particular wavelength can radically change the wavelengths of light that are reflected by the specimen, thus change the apparent color. However, when the specimen is dragged to produce a streak, it is broken into randomly oriented microscopic crystals, small impurities do not affect the absorption of light.
The surface across which the mineral is dragged is called a "streak plate", is made of unglazed porcelain tile. In the absence of a streak plate, the unglazed underside of a porcelain bowl or vase or the back of a glazed tile will work. Sometimes a streak is more or described by comparing it with the "streak" made by another streak plate; because the trail left behind results from the mineral being crushed into powder, a streak can only be made of minerals softer than the streak plate, around 7 on the Mohs scale of mineral hardness. For harder minerals, the color of the powder can be determined by filing or crushing with a hammer a small sample, usually rubbed on a streak plate. Most minerals that are harder have an unhelpful white streak; some minerals leave a streak similar to their natural color, such as lazurite. Other minerals leave surprising colors, such as fluorite, which always has a white streak, although it can appear in purple, yellow, or green crystals. Hematite, black in appearance, leaves a red streak which accounts for its name, which comes from the Greek word "haima", meaning "blood."
Galena, which can be similar in appearance to hematite, is distinguished by its gray streak. Bishop, A. C.. R.. R.. Cambridge Guide to Minerals and Fossils. Cambridge: Cambridge University Press. Pp. 12–13. Holden, Martin; the Encyclopedia of Gemstones and Minerals. New York: Facts on File. p. 251. ISBN 1-56799-949-2. Schumann, Walter. Minerals of the World. New York: Sterling Publishing. Pp. 18–16. ISBN 0-00-219909-2. Physical Characteristics of Minerals, at Introduction to Mineralogy by Andrea Bangert What is Streak? from the Mineral Gallery
Pseudomonas is a genus of Gram-negative, Gammaproteobacteria, belonging to the family Pseudomonadaceae and containing 191 validly described species. The members of the genus demonstrate a great deal of metabolic diversity and are able to colonize a wide range of niches, their ease of culture in vitro and availability of an increasing number of Pseudomonas strain genome sequences has made the genus an excellent focus for scientific research. Because of their widespread occurrence in water and plant seeds such as dicots, the pseudomonads were observed early in the history of microbiology; the generic name Pseudomonas created for these organisms was defined in rather vague terms by Walter Migula in 1894 and 1900 as a genus of Gram-negative, rod-shaped and polar-flagellated bacteria with some sporulating species, the latter statement was proved incorrect and was due to refractive granules of reserve materials. Despite the vague description, the type species, Pseudomonas pyocyanea, proved the best descriptor.
Like most bacterial genera, the pseudomonad last common ancestor lived hundreds of millions of years ago. They were classified at the end of the 19th century when first identified by Walter Migula; the etymology of the name was not specified at the time and first appeared in the seventh edition of Bergey's Manual of Systematic Bacteriology as Greek pseudes "false" and -monas "a single unit", which can mean false unit. Soon, other species matching Migula's somewhat vague original description were isolated from many natural niches and, at the time, many were assigned to the genus. However, many strains have since been reclassified, based on more recent methodology and use of approaches involving studies of conservative macromolecules. 16S rRNA sequence analysis has redefined the taxonomy of many bacterial species. As a result, the genus Pseudomonas includes strains classified in the genera Chryseomonas and Flavimonas. Other strains classified in the genus Pseudomonas are now classified in the genera Burkholderia and Ralstonia.
In 2000, the complete genome sequence of a Pseudomonas species was determined. By 2016, more than 400 strains of Pseudomonas had been sequenced. Sequencing the genomes of hundreds of strains revealed divergent species within the genus. In fact, many genomes of Pseudomonas share only 50-60% of their genes, e.g. P. aeruginosa and P. putida share only 2971 proteins out of 5350. Members of the genus display these defining characteristics: Rod-shaped Gram-negative Flagellum one or more, providing motility Aerobic Non-spore forming Catalase-positive Oxidase-positiveOther characteristics that tend to be associated with Pseudomonas species include secretion of pyoverdine, a fluorescent yellow-green siderophore under iron-limiting conditions. Certain Pseudomonas species may produce additional types of siderophore, such as pyocyanin by Pseudomonas aeruginosa and thioquinolobactin by Pseudomonas fluorescens. Pseudomonas species typically give a positive result to the oxidase test, the absence of gas formation from glucose, glucose is oxidised in oxidation/fermentation test using Hugh and Leifson O/F test, beta hemolytic, indole negative, methyl red negative, Voges–Proskauer test negative, citrate positive.
Pseudomonas may be the most common nucleator of ice crystals in clouds, thereby being of utmost importance to the formation of snow and rain around the world. All species and strains of Pseudomonas have been classified as strict aerobes. Exceptions to this classification have been discovered in Pseudomonas biofilms. A significant number of cells can produce exopolysaccharides associated with biofilm formation. Secretion of exopolysaccharides such as alginate makes it difficult for pseudomonads to be phagocytosed by mammalian white blood cells. Exopolysaccharide production contributes to surface-colonising biofilms that are difficult to remove from food preparation surfaces. Growth of pseudomonads on spoiling foods can generate a "fruity" odor. Most Pseudomonas spp. are resistant to penicillin and the majority of related beta-lactam antibiotics, but a number are sensitive to piperacillin, ticarcillin, or ciprofloxacin. Aminoglycosides such as tobramycin and amikacin are other choices for therapy.
This ability to thrive in harsh conditions is a result of their hardy cell walls that contain porins. Their resistance to most antibiotics is attributed to efflux pumps, which pump out some antibiotics before they are able to act. Pseudomonas aeruginosa is recognized as an emerging opportunistic pathogen of clinical relevance. One of its most worrying characteristics is its low antibiotic susceptibility; this low susceptibility is attributable to a concerted action of multidrug efflux pumps with chromosomally encoded antibiotic resistance genes and the low permeability of the bacterial cellular envelopes. Besides intrinsic r