Sudan–United States relations are the bilateral relations between Sudan and the United States. The United States government has been critical of Sudan's human rights record and has dispatched a strong UN Peacekeeping force to Darfur. Relations between both countries in recent years have greatly improved, with Sudan's post-revolutionary government compensating American victims of al-Qaeda terror attacks, the removal of Sudan from the State Department's blacklist of state sponsors of terrorism and the United States Congress having reinstated Sudan's sovereign immunity in December 2020.

The al-Shifa pharmaceutical factory in Kafouri, Khartoum North, Sudan, was constructed between 1992 and 1996 with components imported from Germany, India, Italy, Sweden, Switzerland, Thailand and the United States. It was opened on 12 July 1997 and bombed by the United States on 20 August 1998. The industrial complex was composed of four buildings. It was the largest pharmaceutical factory in Khartoum and employed over 300 workers, producing medicine both for human and veterinary use.