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Sumter County, South Carolina

Sumter County is a county located in the U. S. state of South Carolina. As of the 2010 census, the population was 107,456, its county seat is Sumter. The county was created in 1800. Sumter County comprises South Carolina Metropolitan Statistical Area, it is the home of Shaw AFB, headquarters to the 9th Air Force, AFCENT, United States Army Central, with a number of other tenant units. It is one of largest bases in the USAF's Air Combat Command. According to the U. S. Census Bureau, the county has a total area of 682 square miles, of which 665 square miles is land and 17 square miles is water, it is drained by its tributaries. Its western border is formed by the Wateree River. One of South Carolina's most famous areas are the High Hills of Santee comprising the western part of the county; the county is one of five that borders Lake Marion known as South Carolina's "Inland Sea." Lee County - north Florence County - northeast Clarendon County - south Calhoun County - southwest Richland County - west Kershaw County - northwest I-95 US 15 US 15 Conn.

US 76 US 76 Bus. US 378 US 378 Bus. US 401 US 521 US 521 Conn. SC 35 SC 37 SC 40 As of the 2010 United States Census, there were 107,456 people, 40,398 households, 28,311 families residing in the county; the population density was 161.6 inhabitants per square mile. There were 46,011 housing units at an average density of 69.2 per square mile. The racial makeup of the county was 48.2% white, 46.9% black or African American, 1.1% Asian, 0.4% American Indian, 0.1% Pacific islander, 1.4% from other races, 1.9% from two or more races. Those of Hispanic or Latino origin made up 3.3% of the population. In terms of ancestry, 7.2% were Subsaharan African, 6.9% were American, 6.1% were English, 5.9% were German, 5.7% were Irish. Of the 40,398 households, 36.5% had children under the age of 18 living with them, 44.6% were married couples living together, 20.2% had a female householder with no husband present, 29.9% were non-families, 25.8% of all households were made up of individuals. The average household size was 2.59 and the average family size was 3.11.

The median age was 35.4 years. The median income for a household in the county was $39,137 and the median income for a family was $45,460. Males had a median income of $36,101 versus $28,421 for females; the per capita income for the county was $18,944. About 15.5% of families and 19.4% of the population were below the poverty line, including 29.1% of those under age 18 and 14.7% of those age 65 or over. Sumter Mayesville Pinewood Horatio Wedgefield Ray Allen, professional NBA basketball player is from Dalzell. David DuBose Gaillard of Fulton Crossroads was in charge of the building of the central portion of the Panama Canal. Angelica Singleton Van Buren, U. S. president's daughter-in-law and from Wedgefield. Sloman Moody, born in Horatio. Bill Pinkney of The Drifters was born in Dalzell. Ja Morant, NCAA basketball player for Murray State University, born in Dalzell and attended high school in Sumter. University of South Carolina Sumter National Register of Historic Places listings in Sumter County, South Carolina Sumter County official website Central Carolina Technical College Sumter County SC Community Sumter Economic Development

Konstantinos Koukidis

Konstantinos Koukidis was the alleged Greek Evzone on flag guard duty on 27 April 1941 at the Athens Acropolis, at the beginning of the Axis occupation of Greece during World War II. After the first Germans climbed up the Acropolis, an officer ordered him to surrender, give up the Greek flag and raise the Nazi swastika flag in its place. Koukidis instead chose to stay loyal to his duty by hauling down the flag, wrapping it around his body and jumping from the Acropolis rock to his death. A commemorative plaque near the spot marks the event. During a television programme on 26 April 2000, the mayor of Athens Dimitris Avramopoulos, stated that there was no specific documentary evidence on Koukidis or his deed, it was noted that a heroic legend of this nature had been important in maintaining national morale under a harsh occupation. On the same occasion, Lieutenant General Ioannis Kakoudakis, Director of the Department of the History of the Army, reported that an investigation had failed to confirm the existence of this soldier.

The Daily Mail original article about Koukidis in 1941 as well as relevant discussion is available online. Manolis Glezos and Apostolos Santas who tore down the Nazi flag from the Acropolis in May 1941 Juan Escutia


Flurazepam is a drug, a benzodiazepine derivative. It possesses anxiolytic, hypnotic and skeletal muscle relaxant properties, it produces a metabolite with a long half-life. Flurazepam came into medical use the same year. Flurazepam, developed by Roche Pharmaceuticals was one of the first benzo hypnotics to be marketed. Flurazepam is indicated for mild to moderate insomnia and as such it is used for short-term treatment of patients with mild to moderate insomnia such as difficulty falling asleep, frequent awakening, early awakenings or a combination of each. Flurazepam is a long-acting benzodiazepine and is sometimes used in patients who have difficulty in maintaining sleep. Intermediate half-life benzodiazepines are useful for patients with difficulty in maintaining sleep. Flurazepam is no longer available in the United States; the FDA posted an update that expected resupply to pharmacies by manufacture is early or mid December of 2019. Flurazepam is now again available in the United States; the most common adverse effects are dizziness, light-headedness, ataxia.

Flurazepam has abuse potential and should never be used with alcoholic beverages or any other substance that can cause drowsiness. Addictive and fatal results may occur. Flurazepam users should only take this drug as prescribed, should only be taken directly before the user plans on sleeping a full night. Next day drowsiness is common and may increase during the initial phase of treatment as accumulation occurs until steady-state plasma levels are attained. A 2009 meta-analysis found a 44% higher rate of mild infections, such as pharyngitis or sinusitis, in people taking hypnotic drugs compared to those taking a placebo. A review paper found that long-term use of flurazepam is associated with drug tolerance, drug dependence, rebound insomnia and central nervous system related adverse effects. Flurazepam is best used for a short time period and at the lowest possible dose to avoid complications associated with long-term use. Non-pharmacological treatment options however, were found to have sustained improvements in sleep quality.

Flurazepam and other benzodiazepines such as fosazepam, nitrazepam lost some of their effect after seven days administration in psychogeriatric patients. Flurazepam shares cross tolerance with barbiturates and barbiturates can be substituted by flurazepam in those who are habituated to barbiturate sedative hypnotics. After discontinuation of flurazepam a rebound effect or benzodiazepine withdrawal syndrome may occur about four days after discontinuation of medication. Benzodiazepines require special precaution if used in the elderly, during pregnancy, in children, alcohol- or drug-dependent individuals and individuals with comorbid psychiatric disorders. Flurazepam, similar to other benzodiazepines and nonbenzodiazepine hypnotic drugs causes impairments in body balance and standing steadiness in individuals who wake up at night or the next morning. Falls and hip fractures are reported; the combination with alcohol increases these impairments. Partial, but incomplete tolerance develops to these impairments.

An extensive review of the medical literature regarding the management of insomnia and the elderly found that there is considerable evidence of the effectiveness and durability of non-drug treatments for insomnia in adults of all ages and that these interventions are underutilized. Compared with the benzodiazepines including flurazepam, the nonbenzodiazepine sedative-hypnotics appeared to offer few, if any, significant clinical advantages in efficacy in elderly persons. Tolerability in elderly patients, however, is improved marginally in that benzodiazepines have moderately higher risks of falls, memory problems, disinhibition when compared to non-benzodiazepine sedatives, it was found that newer agents with novel mechanisms of action and improved safety profiles, such as the melatonin agonists, hold promise for the management of chronic insomnia in elderly people. Chronic use of sedative-hypnotic drugs for the management of insomnia does not have an evidence base and has been discouraged due to concerns including potential adverse drug effects as cognitive impairment, daytime sedation, motor incoordination, increased risk of motor vehicle accidents and falls.

In addition, the effectiveness and safety of long-term use of sedative hypnotics has been determined to be no better than placebo after 3 months of therapy and worse than placebo after 6 months of therapy. Flurazepam is a "classical" benzodiazepine. Flurazepam generates an active metabolite, N-Desalkylflurazepam with a long elimination half-life. Flurazepam could be therefore unsuitable as a sleeping medication for some individuals due to next-day sedation. Residual'hangover' effects after nighttime administration of flurazepam, such as sleepiness, impaired psychomotor and cognitive functions, may persist into the next day, which may impair the ability of users to drive safely and increase risks of falls and hip fractures. Flurazepam is lipophilic, is metabolized hepatically via oxidative pathways; the main pharmacological effect of flurazepam is to increase the effect of GABA at the GABAA receptor via binding to the benzodiazepine site on the GABAA receptor causing an increase influx of chloride ions

JACC: Cardiovascular Interventions

JACC: Cardiovascular Intervention is a peer-reviewed sub-specialty medical journal published by Elsevier for the American College of Cardiology since 2008. The journal focus on articles on interventional cardiology, encompassing cardiac coronary and non-coronary interventions, including peripheral arteries and cerebrovasculature; the majority of articles report results from clinical trials illustrating evidence to inform and alter practice guidelines and experimental studies describing improved technologies and understanding of cardiac disease. The journal has a 5-Year Impact Factor of 9.605, is part of the American College of Cardiology journal family, is ranked among the top 10 cardiology journals. The journal is indexed by Medline and scopus. Journal of the American College of Cardiology JACC Cardiovascular Imaging European Heart Journal Circulatory system Official website

Lake Francis (Murphy Dam)

Lake Francis is a reservoir on the Connecticut River in northern New Hampshire, United States. The lake is located in Coos County, east of the village of Pittsburg and along the boundary between the towns of Pittsburg and Clarksville; the lake is impounded by Murphy Dam, built in 1940 as a flood control project. The 117-foot earthen dam is owned by the Water Division of the state's Department of Environmental Services, is operated by TC Energy. Lake Francis and Murphy Dam are named after Francis P. Murphy, who served as the Governor of New Hampshire from 1937 to 1941; the lake covers nearly 2,000 acres, has a capacity of 131,375 acre feet, has average and maximum depths of 40 feet and 82 feet, respectively. The lake is classified as a coldwater fishery, with observed species including rainbow trout, brown trout, landlocked salmon, lake trout, chain pickerel. There are two public boat launch locations, ice fishing is permitted from January through March. Lake Francis State Park is located on the northeast side of the lake, where the Connecticut River flows in.

North of Lake Francis is Back Lake. List of lakes in New Hampshire Lake Francis Flight via YouTube

The Lost World (2001 film)

The Lost World is a 2001 adaptation of the novel of the same name by Arthur Conan Doyle, directed by Stuart Orme and adapted by Tony Mulholland and Adrian Hodges. It was filmed at various locations on the West Coast of New Zealand; the mini-series consisted of two 75 minute episodes which were broadcast on BBC One on 25 and 26 December 2001, receiving 8.68 million and 6.98 million viewers respectively. Bob Hoskins played Professor Challenger and was supported by James Fox, Peter Falk, Matthew Rhys, Tom Ward and Elaine Cassidy. While in the Amazon rainforest, Professor George Challenger shoots an animal he believes to be a pterosaur. Returning to England, Challenger crashes a lecture at the Natural History Museum held by his rival, Professor Leo Summerlee. Challenger proposes an expedition to discover the home of the pterosaur, but is dismissed by the science community. However, hunter Lord John Roxton, Daily Gazette columnist Edward Malone both volunteer to join and finance the expedition. A sceptical Summerlee joins.

On the voyage to South America, Challenger reveals a map created by a Portuguese man named Father Luis Mendoz leading to a remote Brazilian plateau where he encountered dinosaurs during a previous expedition. They travel to a Christian mission in the Amazon, meeting Agnes Clooney and her uncle Reverend Theo Kerr, who condemns Charles Darwin's theory of evolution. Roxton takes a liking to Agnes’ unladylike behaviour and flirts with her. Agnes volunteers to join the expedition as a translator. However, in the jungle, the expedition's porters flee out of superstition, but Kerr arrives trying to convince the bull-headed Challenger to turn back, they reach the edge of the plateau and find a cave concealing a pathway to the plateau but discover a blockage. They find a gorge leading straight to the plateau, using a tree as a substitute bridge. However, when all but Kerr make it across, he knocks the tree into the gorge and leaves Challenger and the others stranded. Venturing in the plateau's jungle, they find several species of dinosaur, a flock of pterosaurs, a strange species of aggressive, carnivorous ape men.

Malone finds a lake. Malone and Agnes evade it when it falls into a manmade trap, they find Roxton, learning the apes kidnapped Summerlee. Warriors from an indigenous tribe appear, aiding them in rescuing the professors, along with Achille, the son of their own chieftain; the ape men are taken captive by the tribe. Arriving at the village, the tribe are revealed to be surviving members of Mendoz's expedition and mistake Challenger for Mendoz, who taught them Christianity; the chief shows the other end of the cave and reveals it was blocked by a man who visited the tribe, trapping them within the plateau. Roxton falls in love with the chief's daughter Maree, a woman, quite similar to him, they marry; some time the ape men cry out after having to bury one of their children, attracting the attention of two Allosaurs who rampage on the tribe. In the mayhem, the chief is killed, as well as several other tribe members, but Malone and Roxton slay the dinosaurs. At the same time, Summerlee reopens the cave using explosives, allowing the explorers to flee the village when Achille condemns them.

Roxton buys time for the others to leave. Roxton succumbs to his wounds and is mourned by the villagers. Challenger, Summerlee and Agnes return to the Amazon but encounter a crazed Kerr and realise he sealed the cave to prevent anyone from finding it, believing it to be forged by Satan because of the ape-men; when Kerr produces a revolver, Summerlee wrestles him for it, only for Kerr to be shot and killed by accident. The expedition porters find the survivors. Returning to London, Malone discovers Gladys has become engaged to another man, however he is glad, as he realises that he has developed feelings for Agnes. At Challenger's press event, he unveils a juvenile Pteranodon. However, the excited crowd scare the Pteranodon out of a window. Malone and Summerlee convince Challenger to pretend the whole expedition was a lie to protect the plateau's inhabitants from destruction, sacrificing his reputation and success for the safety of the Dinosaurs and the villagers. Summerlee stays with his family, Challenger sets off to find Atlantis, while Malone and Agnes admit their love for each other, Malone decides to pursue a career as a novelist.

In a final scene, Roxton is revealed to be living with the villagers in peace. Bob Hoskins as Professor George Challenger James Fox as Professor Leo Summerlee Tom Ward as Lord John Roxton Matthew Rhys as Edward Malone Elaine Cassidy as Agnes Clooney Peter Falk as Reverend Theo Kerr Joanna Page as Gladys Tom Goodman-Hill as Arthur Hare Robert Hardy as Professor Illingworth The Lost World was released on home video as a single 145-minute instalment; the series was released on VHS and DVD in the United Kingdom on June 3, 2002. An American DVD release followed on October 29, 2002, presented in 4:3 pan and scan format with a stereo soundtrack; this release contained the 90-minute History Channel documentary Dinosaur Secrets Revealed and a 21-minute documentary on the making of the series. John Leonard TV critic for New York magazine praised the special effects for the time, saying "New Zealand looks like Brazil, the beasts are the best on a small screen." Writing for DVD Talk, Holly E Ordway described the series as "a straightforward and entertaining adventure story", praising the modernised changes made to the book's storyline