Surxondaryo Region, old spelling Surkhandarya Region is a region (viloyat) of Uzbekistan, located in the extreme south-east of the country. Established on March 6, 1941, it borders on Qashqadaryo Region internally, and Turkmenistan, Afghanistan and Tajikistan externally, going anticlockwise from the north. It takes its name from the river Surxondaryo, that flows through the region. It covers an area of 20,100 km². The population is estimated at 2,743,201, with 80% living in rural areas. According to official data, 83% of the population are Uzbeks and 12,5% Tajiks, but several sources argue that the Tajik population might be significantly higher in this region , as well as in Samarkand and Bukhara. The highest point of the Region and also of Uzbekistan is Khazrati Sulton peak reaching 4,643 m/15,233 ft in Gissar Range.

Uzbek, formerly known as Turki, is a Karluk Turkic language spoken by Uzbeks. It is the official and national language of Uzbekistan and formally succeeded Chagatai, an earlier Karluk language also known as "Turki", as the literary language of Uzbekistan in the 1920s.