The Susquehanna River is a major river located in the Mid-Atlantic region of the United States, overlapping between the lower Northeast. At 444 miles (715 km) long, it is the longest river on the East Coast of the United States. By watershed area, it is the 16th-largest river in the United States, and also the longest river in the early 21st-century continental United States without commercial boat traffic.

The Appalachian Mountains, often called the Appalachians, are a mountain range in eastern to northeastern North America. The term "Appalachian" refers to several different regions associated with the mountain range, and its surrounding terrain. The general definition used is one followed by the United States Geological Survey and the Geological Survey of Canada to describe the respective countries' physiographic regions. The U.S. uses the term Appalachian Highlands and Canada uses the term Appalachian Uplands; the Appalachian Mountains are not synonymous with the Appalachian Plateau, which is one of the provinces of the Appalachian Highlands.