Switzerland participated in the Eurovision Song Contest 2021 with the song "Tout l'univers" written by Gjon Muharremaj, Wouter Hardy, Nina Sampermans and Xavier Michel. The song was performed by Gjon's Tears, which is the artistic name of singer Gjon Muharremaj who was internally selected by the Swiss broadcaster Swiss Broadcasting Corporation to represent the nation at the 2020 contest in Rotterdam, Netherlands, after they were due to compete in the 2020 contest with "Répondez-moi" before the 2020 event's cancellation. "Tout l'univers" was presented to the public as the Swiss entry on 10 March 2021.

Switzerland has participated in the Eurovision Song Contest 63 times since making its debut at the first contest in 1956, missing only four contests, in 1995, 1999, 2001 and 2003. Switzerland hosted the first contest in 1956 in Lugano, and won it. Switzerland won the contest again in 1988 and 2024.