Synodontis grandiops is a species of upside-down catfish endemic to the Democratic Republic of the Congo, Burundi, and Tanzania, where it is only known from Lake Tanganyika. It was first described by Jeremy John Wright and Lawrence M. Page in 2006, from specimens collected at multiple points along the shore of Lake Tanganyika. The species name is a Latinized combination of the Latin "grandi", meaning large or big, and the Greek "ops", meaning eye, a reference to the relatively large eyes of this fish.

Lake Tanganyika is an African Great Lake. It is the second-oldest freshwater lake in the world, the second-largest by volume, and the second deepest, in all cases after Lake Baikal in Siberia. It is the world's longest freshwater lake. The lake is shared among four countries—Tanzania, the Democratic Republic of the Congo, Burundi, and Zambia—with Tanzania (46%) and the DRC (40%) possessing the majority of the lake. It drains into the Congo River system and ultimately into the Atlantic Ocean.