Synovial membrane
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The synovial membrane is a specialized connective tissue that lines the inner surface of capsules of synovial joints, tendon sheaths, and synovial bursas. It makes direct contact with the fibrous memb
Synovial joint
Histology of a synovial membrane. H&E stain.
Hyaluronic acid
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Hyaluronic acid, also called hyaluronan, is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is unique among glycosaminoglycans as
Synovial membrane
…known as fibroblast-like synoviocytes (FLS). Type A cells maintain the synovial fluid by removing wear-and-tear debris. The FLS (type B cells) produce hyaluronan, as well as other extracellular components in the synovial fluid. The synovial membrane is variable but often has two layers…
Precursor 1: Synthesis of UDP-Glucuronic Acid
Precursor 2: Synthesis of UDP-N-Acetylglucosamine
Final step of HA Synthesis