The Syro-Malabar Cathedral of St Alphonsa is a Catholic cathedral of the Syro-Malabar rite in Preston, Lancashire. It is the cathedral of the Syro-Malabar Catholic Eparchy of Great Britain, and was previously St Ignatius Church under the Diocese of Lancaster. It is situated close to the Preston city centre, with the entrance on Meadow Street. The building was opened in 1836 and was the first church in Preston to have a spire.

Preston is a city on the north bank of the River Ribble in Lancashire, England. The city is the administrative centre of the county of Lancashire and the wider City of Preston local government district. Preston and its surrounding district obtained city status in 2002, becoming England's 50th city in the 50th year of Queen Elizabeth II's reign. Preston has a population of 114,300, the City of Preston district 132,000 and the Preston Built-up Area 313,322. The Preston Travel To Work Area, in 2011, had a population of 420,661, compared with 354,000 in the previous census.