The 2010 TLC: Tables, Ladders & Chairs was the second annual TLC: Tables, Ladders & Chairs professional wrestling pay-per-view (PPV) event produced by World Wrestling Entertainment (WWE). It was held for wrestlers from the promotion's Raw and SmackDown brand divisions. The event took place on December 19, 2010, at the Toyota Center in Houston, Texas. It was the last TLC held under the first brand split, which ended in August 2011, but was reinstated in July 2016.

Toyota Center is an indoor arena located in Houston. It is named after the Japanese automobile manufacturer Toyota. The arena is home to the Houston Rockets of the National Basketball Association (NBA), and it was once the home of the Houston Aeros of the American Hockey League (AHL), and the Houston Comets of the Women's National Basketball Association (WNBA).