Tadcaster is a market town and civil parish in the Selby district of North Yorkshire, England, 3 miles east of the Great North Road, 12 miles north-east of Leeds, 10 miles south-west of York. The River Wharfe joins the River Ouse about 10 miles downstream from it. Tadcaster is twinned with Saint-Chély-d'Apcher in France; the Romans built a settlement and named it Calcaria from the Latin word for lime, reflecting the importance of the area's limestone geology as a natural resource for quarrying, an industry which continues and has contributed to many notable buildings including York Minster. Calcaria was an important staging post that grew at the crossing of the River Wharfe on the road to Eboracum; the suffix of the Anglo-Saxon name Tadcaster is derived from the borrowed Latin word castra meaning'fort', although the Angles and Saxons used the term for any walled Roman settlement. Tadcaster is first mentioned in the Anglo-Saxon Chronicle, where it appears as Táda, referring to the place where King Harold assembled his army and fleet before entering York and proceeding onwards to the Battle of Stamford Bridge in 1066.

The town is mentioned in the 1086 Domesday Book as "Tatecastre". The record reads: Two Manors. In Tatecastre and Turchil had eight carucates of land for geld, where four ploughs may be. Now, William de Parci has three ploughs and 19 villanes and 11 bordars having four ploughs, two mills of ten shillings. Sixteen acres of meadow are there; the whole manors, five quaranteens in length, five in breadth. In King Edward's time they were worth forty shillings; the place-name means'Tata's Roman fort'. In the 11th century William de Percy established a motte-and-bailey fortress, near the present town centre using stone reclaimed from Roman rubble; the castle was abandoned in the early-12th century, although re-fortified with cannon emplacements during the Civil War, all that remains is the castle motte. The outline of the long-demolished southern bailey still impacts the geography of surrounding streets; the original river crossing was a ford near the site of St Mary's Church, followed by a wooden bridge.

Around 1240, the first stone bridge was constructed close by from stone reclaimed from the castle. At 11 am on Tuesday 7 December 1642 the Battle of Tadcaster, an incident during the English Civil War, took place on and around Tadcaster Bridge between Sir Thomas Fairfax's Parliamentarian forces and Sir Thomas Glemham's Royalist army; the bridge over the Wharfe was constructed on the foundations of the stone original in around 1700, although it has been modified at least twice since. The bridge marks the boundary between the West Riding and the Ainsty of York. Important people would have been formally greeted here on their journey to York. A market has been held since 1270, when Henry de Percy obtained a royal charter from Henry III to hold'a market and fair at his manor of Tadcaster', to be held each Tuesday; the ancient market place is at the junction of Bridge Street. A stone base, believed to have been part of the original market cross stood on Westgate where the Tadcaster War Memorial now stands.

The present-day market is held on Thursdays on the car park of Tadcaster Social Club on St Josephs Street. For local government purposes, the River Wharfe divides the town into eastern and western electoral wards; the combined population of Tadcaster East and Tadcaster West in 2004 was 7,280, 3,800 in Tadcaster East and 3,480 in Tadcaster West. The local authority is Selby District Council. Tadcaster gave its name to a much larger rural district council, Tadcaster Rural District and other administrative areas; this may lead to confusion when comparing the size and extent of the current town with information for earlier periods. For example, the population in 1911 of the Tadcaster sub-district was 6831 compared with that of the Tadcaster Registration District, 32052. Tadcaster elects a mayor on an annual basis. Tadcaster has a long association with the brewing industry because of the quality and accessibility of the local water supply. Rich in lime sulphate after filtering through limestone, in the right conditions freshwater springs - known locally as popple-wells - still bubbling up near St Mary's church.

Tax registers from 1341 record the presence of two thriving breweries or brewhouses in the town, one paying 8d in tax and the other 4d. Today it is second in importance only to Burton-upon-Trent as an English brewing centre. Three breweries have survived to the present day, The Tower Brewery, John Smith's and Samuel Smith's Old Brewery, the oldest brewery in Yorkshire and only remaining independent brewery in Tadcaster. A fourth brewery stood by the river on the site of the present central car park. Sam Smith's draft horses are a common sight on the streets of the town; the three breweries employ a large number of local people. Local newspapers covering Tadcaster include the Wetherby News; the major regional newspaper in the area is the Yorkshire Post. The local BBC radio station is Radio York, commercial stations include Minster FM and Capital Yorkshire. A leisure centre on Station Road provides for a variety of sport activities, is the base for private sports clubs and a physiotherapy clinic.

Tadcaster's community swimming pool, which includes a fitness suite, opened in December 1994. At the end of 2007 the pool underwent repairs costing £130,000, reopening in 2008; the route of The White Rose Way, a long distance walk from Lee

Ana Ivanovic won her first and only Grand Slam singles title, beating first-time finalist Dinara Safina, 6–4, 6–3 to win the Women's Singles tennis title at the 2008 French Open. Ivanovic became the new WTA singles No. 1 by reaching the final. Maria Sharapova, Jelena Janković and Svetlana Kuznetsova were in contention for the No. 1 ranking at the start of the tournament. Safina had come from a set and match point down in both her fourth round and quarterfinal matches against Sharapova and Elena Dementieva, respectively. Justine Henin was the three-time defending champion, but she retired from the sport on May 14, 2008, her retirement left Serena Williams as the only former French Open champion remaining in the women's draw. Williams was defeated in the third round by Katarina Srebotnik, meaning that there would be a first-time French Open champion in 2008; this was the first Grand Slam main draw appearance of future world No. 2 and two-time Grand Slam champion Petra Kvitová, who lost to Kaia Kanepi in fourth round.

Click on the seed number of a player to go to their draw section. Draw and Qualifying Draw

Virginia Man-Yee Lee is a Chinese-born American neuropathologist who specializes in the research of Alzheimer's disease. She is the John H. Ware 3rd Professor in Alzheimer's Research in the Department of Pathology and Laboratory Medicine at the Perelman School of Medicine at the University of Pennsylvania, Director of the Center for Neurodegenerative Disease Research and Co-director of the Marian S. Ware Alzheimer Drug Discovery Program, she was awarded the 2020 Breakthrough Prize in Life Sciences. Lee was born in 1945 in Chongqing, Republic of China, moved to Hong Kong with her family at age five, she received a Chinese education before moving to a high school with English as its language of instruction. Lee studied piano at the Royal Academy of Music in London, obtained an MS in Biochemistry from the University of London in 1968 and a PhD in Biochemistry from the University of California at San Francisco in 1973, she was a postdoctoral fellow at the Rudolf Magnus Institute of the University of Utrecht in the Netherlands and at Children's Hospital Medical Center and Harvard Medical School in Boston where she met her husband, John Trojanowski.

She was appointed Associate Senior Research Investigator at Smith-Kline & French, Inc. in Philadelphia from 1979-1980. After not being able to pursue her passion in neuroscience, she joined the faculty of the Department of Pathology and Laboratory Medicine at the Perelman School of Medicine of the University of Pennsylvania in 1981, attaining the rank of Professor in 1989. Here, she teamed up with Trojanowski to study brain samples for signs of disease, she received an MBA in 1984 from the Executive MBA program at the Wharton School of the University of Pennsylvania just in case her research career was not successful. Lee and her husband oversee a lab with about 50 employees, publishing 15 to 20 studies per year. Dr. Lee’s research focuses on proteins that form pathological inclusions in Alzheimer’s disease, Parkinson’s disease, frontotemporal degeneration, amyotrophic lateral sclerosis and related neurodegenerative disorders, her work demonstrated that tau, alpha-synuclein and TDP-43 proteins form unique inclusions in neurodegenerative diseases and that aggregation of these proteins is a common mechanistic theme in AD, PD, FTLD, ALS and related disorders.

Dr. Lee’s studies implicated the abnormal aggregation of tau, alpha-synuclein and TDP-43 in mechanisms that compromise neuronal viability. Major accomplishments include discovery of tau, alpha-synuclein and TDP-43 as the diseases proteins in AD, PD and ALS/FTD elucidating the roles of these proteins in neurodegeneration, pursuing pathological tau as a target for AD and FTD drug discovery, how the transmission of pathological tau and alpha-synuclein explains the progression of AD and PD. Most this research has opened up new avenues of research to identify targets for drug discovery to develop better treatments for these disorders; because of the broad impact of her research, Dr. Lee’s h-index is 150 and she is listed among the 10 most cited AD researchers from 1985-2008 as well as among the top 400 most influential biomedical researchers from 1996-2011. ISI has recognized Dr. Lee as an ISI Highly Cited Researcher which places her in the top 10 most cited neuroscientists from 1997 to 2007 Among other distinctions, Lee won both the Pasarow Award in neuropsychiatry and the John Scott Award in 2012.

She was awarded the 2020 Breakthrough Prize in Life Sciences for which she was awarded $3 million that she plans to spend on continuing her research. 1991 Metropolitan Life Foundation Award for Alzheimer Disease Research 1991-1994 Zenith Award for Alzheimer's Disease Research, Alzheimer's Association, Inc 1992 Allied Signal Award for Aging Research 1997 Rita Hayworth Award for Medical Research in Alzheimer's Disease 1998 Potamkin Prize for Medical Research in Alzheimer's Disease 2000 Stanley Cohen Biomedical Research Award 2004-present AAUW Founders Distinguished Senior Scholar Award 2008 Franklin Founder Award 2008: Celebrating Women in Science 2009 Life Time Achievement Award in Alzheimer’s Disease Research, Alzheimer’s Association 2012 John Scott Award 2013 10th Parkinson Society Canada’s Donald Calne Award and Lectureship 2018 Robert A. Pritzker Award for Leadership in Parkinson’s Disease Research from the Michael J. Fox Foundation 2018 Helis Foundation Award for Parkinson’s and Neurodegenerative Disease Research 2020 Breakthrough Prize in Life Sciences

Kendra Suzanne Horn is an American attorney and politician serving as the U. S. Representative for Oklahoma's 5th congressional district since 2019. A member of the Democratic Party, her district includes all of Oklahoma City, she defeated two-term incumbent Republican Steve Russell in the 2018 election. Horn is the first Democrat to represent the state's 5th congressional district in 44 years and the first Oklahoma Democrat elected to Congress in eight years, she is the third woman elected to Congress from Oklahoma, after Alice Robertson and Mary Fallin, the first Democratic woman elected to the House from Oklahoma. Horn received the Gold Award. Horn graduated with a bachelor's degree in Political Science from the University of Tulsa in 1998. In 2001, Horn graduated from Southern Methodist University Dedman School of Law, she studied at the International Space University in Strasbourg, France. Kendra Horn worked in private practice as a lawyer at a small firm in Dallas, Texas before opening a solo practice in 2002.

Horn was hired on as press secretary to United States Congressman Brad Carson from 2004 to 2005. She went on to work for the Space Foundation first as Manager of Government Affairs at their D. C. office and as the Manager of Communication and Media Relations until 2008. She managed the gubernatorial campaign of Joe Dorman in 2014, she has worked as a strategic consultant with Amatra, a communication technology firm, since 2009. She is one of the founders of Women Lead Oklahoma, a nonpartisan nonprofit that trains and supports women to encourage community and civic action. On July 3, 2017, Horn announced her candidacy for the Democratic nomination for United States House of Representatives to Oklahoma's fifth congressional district. After receiving 44% of the vote in the Democratic primary on June 26, 2018, Horn and primary opponent Tom Guild advanced to the primary runoff. During the August 28 primary, Horn received 76% of the vote defeating Tom Guild and becoming the Democratic nominee. Kendra Horn defeated Republican Steve Russell in the November 6 general election with 50.7% to his 49.3% of the vote, in what was considered one of the biggest upset victories of the cycle.

On January 3, 2019, the first day of the 116th United States Congress, Congresswoman Horn joined 219 other Democrats to support Nancy Pelosi in the chamber-wide election for Speaker of the United States House of Representatives. When explaining her decision to support Pelosi, Horn mentioned that the Democratic and Republican nominees were Pelosi and Kevin McCarthy and said that Pelosi's support for improving health care, strengthening Medicare and Social Security, supporting public education aligned with her successful campaign platform in the 2018 election and therefore with her goals in Congress; the admission of Horn to the New Democrat Coalition was announced on January 23. On January 29, Horn announced she was joining the Blue Dog Coalition, a group of moderate and conservative Democrats. On December 18, 2019, Horn voted for both articles of impeachment against President Donald J. Trump. Committee on Armed ServicesSubcommittee on Readiness Subcommittee on Strategic Forces Committee on Science and TechnologySubcommittee on Energy Subcommittee on Space and Aeronautics Blue Dog Coalition New Democrat Coalition On November 6, 2018, in what was considered one of the biggest upsets in the nation in the 2018 midterms, Horn defeated incumbent Republican Congressman Steve Russell 50.7% to 49.3% in an upset not foreseen by most major observers.

Nearly every major rating organization believed Russell would win, FiveThirtyEight only gave Horn a seven percent chance of winning. Horn won by defeating Russell in Oklahoma County, home to three-fourths of the district's population, by 9,900 votes, more than three times the overall margin of 3,300 votes; when Horn took office, she became the first Democrat to represent the district since John Jarman in 1974, who switched parties to become a Republican midway through what would be his final term. United States House of Representatives Elections Horn was raised in Chickasha, Oklahoma, she is an Episcopalian. Women in the United States House of Representatives Congresswoman Kendra Horn official U. S. House site Congressional campaign website Biography at the Biographical Directory of the United States Congress Profile at Vote Smart Financial information at the Federal Election Commission Legislation sponsored at the Library of Congress Appearances on C-SPAN

Park Jong-sei spelled Park Jong-se, is a South Korean chemistry researcher and former government official. He rose to worldwide notice during the 1988 Summer Olympics in Seoul for his role in detecting Ben Johnson's steroid use, he was the head of South Korea's Food and Drug Administration under President Kim Dae-jung from March 1998 until January 1999, founded protein microarray development start-up Lab Frontier in 2002. A graduate of Seoul University's Department of Chemistry, Park moved to the United States for higher studies in 1966, where he attended graduate school at the University of Rochester and did postdoctoral research at Georgetown University before joining the faculty of Johns Hopkins University, he naturalised as a U. S. worked for the government of Maryland's Department of Health and Mental Hygiene. Park moved back to South Korea in 1986, where he served as head of the Korea Institute of Science and Technology's Applied Sciences Division, he resumed his original South Korean citizenship and relinquished U.

S. citizenship in 1996 before joining the Food and Drug Administration, as South Korea did not permit dual citizenship at the time. In his capacity at KIST, Park was involved with drug testing at the 1988 Summer Olympics in Seoul as head of the Olympic Doping Control Center. There, he was responsible for the detection of stanozolol in urine and blood samples from Ben Johnson which resulted in the latter being stripped of his gold medal. Park took great care in performing the urinalysis, repeated the test procedure from scratch to be sure of his results before reporting the sample to International Olympic Committee officials. ABC World News named him "Person of the Week" on 30 September 1998 for his role in bringing the scandal to light, he detected marijuana usage by three athletes, though no action was taken against them as marijuana was not a banned performance-enhancing substance. Park clashed with Olympics officials over other aspects of how he did his job, made angry comments to the Washington Post about false samples with trace amounts of banned substances, planted among genuine samples in his lab.

His work at the Olympic Doping Control Center earned him the Scientist of the Year Award by the Korea Science Journalists Association. Park was appointed head of the Food and Drug Administration in March 1998, his appointment came as a surprise to observers, as he was a scientist in what was viewed as a political position. In his new capacity, he conducted a shake-up of the administration, replacing seven long-serving officers and recruiting more than 40 new scientists from South Korea and overseas. Park's disregard for earlier seniority-based promotion procedures elicited opposition from the bureaucracy, the Chosun Ilbo reported that some disgruntled anti-reformists in the administration had made anonymous denunciations to prosecutors about Park's alleged receipt of bribes, resulting in an investigation of him just months after he was appointed to his new position. In January 1999, Park was arrested on bribery charges, with prosecutors stating that for several years beginning in 1992, a local pharmaceutical company executive had paid him ₩185 million in bribes for his aid in getting the company's drugs approved.

Park's arrest was part of President Kim Dae-jung's crackdown on corruption in the medical industry, was followed in February by the arrest of Park's director-general of pharmaceutical safety Kim Yon-pan. Park was convicted on the charges and sentenced to three years in prison and five years of probation, he served two years of his sentence, was released in 2000. In 2002, Park founded Lab Frontier, a biotechnology start-up which collaborated with Ewha Womans University on protein microarray development, he later became president of the Bio Venture Association. In November 2007, he was arrested on fraud charges relating to alleged falsification of pharmaceuticals trial reports used to get regulatory approval for pharmaceuticals, on the basis of a tip from a paid informant which led to indictments of 22 other researchers. Seung, Sang-Ae. "The relative importance of oxidative stress versus arylation in the mechanism of quinone-induced cytotoxicity to platelets". Chemico-Biological Interactions. 113: 133–144.

Doi:10.1016/S0009-279700024-6. Yoon, Kyung-Hwan. "Simultaneous determination of amoxicillin and clavulanic acid in human plasma by HPLC–ESI mass spectrometry". Journal of Chromatography B. 813: 121–127. Doi:10.1016/j.jchromb.2004.09.018

Ligdia adustata, the scorched carpet, is a moth of the family Geometridae. The species Latin name adusta, meaning burnt, refers to the scorched appearance of the wings of these moths; the wingspan is 25–30 mm. The basic color of the wings is glossy white, creamy light brownish; the basal area of the forewings is dark brown and can sometimes be blue-grey. Across the forewings near the outer margin there is a brown wavy band. Hindwings are whitish with wavy pale brown lines on the wavy outer edges; the underside of the wings is suffused with reddish brown. Larvae are moderately stout, bright green with red dorsal spots, a red lateral blotch on the 1st—2nd abdominals and red marks on claspers; the pupae are red-brown with blackish wings. Ligdia adustata has two generations per year; the adults fly in April–May, in July–August, but the flight season varies depending on the location within the distribution range. These moths are active from dusk onwards; the larvae feed on spindle (Euonymus europaeus, Euonymus verrucosa and on Berberis species.

The species overwinters as a pupa. This species can be found in the Near East; this moth is common in various environments in shrubs, deciduous forests, thickets and gardens. Lepiforum.de