The Tadjourah Region Somali: Gobolka Tajoora, Afar: Rakaakay Tagórri) is a region in north-central Djibouti, the largest of its six regions. With its capital at Tadjourah, it has an area of 7,100 square kilometres. It lies along the Gulf of Tadjoura, and the coastal city of Tadjoura. The region has active salt and fisheries industries, and is served by the Tadjoura Airport. In total area, it is larger than Brunei and smaller than Cyprus.

Tadjoura is one of the oldest towns in Djibouti and the capital of the Tadjourah Region. The town rose to prominence in the early 19th century as an alterative port to nearby Zeila. Lying on the Gulf of Tadjoura, it is home to a population of around 45,000 inhabitants. It is the third-largest city in the country after Djibouti and Ali Sabieh.