Tailem Bend railway station is located on the Adelaide-Wolseley line in Tailem Bend, South Australia. It is also the junction point for the Loxton and Pinnaroo lines.

Tailem Bend is a rural town in South Australia, 85 kilometres south-east of the state capital of Adelaide. It is located on the lower reaches of the River Murray, near where the river flows into Lake Alexandrina. It is linear in layout since it is constrained by river cliffs on its western side and the Adelaide–Melbourne railway line is dominant on its eastern side. The town grew and consolidated through being a large railway centre between the 1890s and 1990s; now it continues to service regional rural communities. In the 2021 census, Tailem Bend and the surrounding area had a population of 1,705.