Tajikistan sent a delegation to compete at the 2010 Winter Olympics in Vancouver, British Columbia, Canada from 12–28 February 2010. The nation was participating in its third Winter Olympic Games. The Tajikistani delegation consisted of a single athlete: alpine skier Andrei Drygin. Drygin's best finish in any of his events was 44th in the super-G.

The Men's Downhill competition of the Vancouver 2010 Olympics was held at Whistler Creekside in Whistler, British Columbia. The competition was scheduled for Saturday, February 13, but was postponed due to rain and warm temperatures; it was held on Monday, February 15.