Takanabe Domain was a feudal domain under the Tokugawa shogunate of Edo period Japan, in what is now central Miyazaki Prefecture. It was centered around Takanabe Castle and was ruled by the tozama daimyō Akizuki clan for all of its history. In its early years, it was called Takarabe Domain (財部藩) after the location of its original seat.

The Akizuki clan was a Japanese samurai clan who ruled Takanabe Domain of what is now part of Miyazaki Prefecture in Kyushu Japan under the Edo period Tokugawa shogunate. In the Meiji period, the former daimyō became part of the kazoku peerage, with Tsugaru Tsuguakira receiving the title of shishaku (Viscount).