Hedjkheperre Setepenre Takelot II Si-Ese was a pharaoh of the Twenty-third Dynasty of Ancient Egypt in Middle and Upper Egypt. He has been identified as the High Priest of Amun Takelot F, son of the High Priest of Amun Nimlot C at Thebes, and thus, the son of Nimlot C and grandson of king Osorkon II, according to the latest academic research. Based on two lunar dates belonging to Takelot II, this Upper Egyptian pharaoh is today believed to have ascended to the throne of a divided Egypt in either 845 BC or 834 BC. Most Egyptologists today, including Aidan Dodson, Gerard Broekman, Jürgen von Beckerath, M.A. Leahy, and Karl Jansen-Winkeln, also accept David Aston's 1989 hypothesis that Shoshenq III was Osorkon II's actual successor at Tanis, rather than Takelot II. As Aidan Dodson and Dyan Hilton write in their comprehensive book on the royal families of Ancient Egypt:Takelot II is likely to have been identical with the High Priest Takelot F, who is stated in [the] Karnak inscriptions to have been a son of Nimlot C, and whose likely period of office falls neatly just before Takelot II's appearance.

The Twenty-third Dynasty of Egypt is usually classified as the third dynasty of the ancient Egyptian Third Intermediate Period. This dynasty consisted of a number of Meshwesh kings, who ruled either as pharaohs or as independent kings of parts of Upper Egypt from 880 BC to 720 BC, and pharaohs from 837 BC to 728 BC.