Talagante is a commune and the capital city of the province of the same name in the Santiago Metropolitan Region of central Chile. The word Talagante in Quechua comes from talacanta, meaning "Lazo de Hechicero", which was the proper name of the curaca, or ruler, who dominated this central valley on behalf of the Inca empire during the arrival of the Spaniards.

Santiago Metropolitan Region is one of Chile's 16 first-order administrative divisions. It is the country's only landlocked administrative region and contains the nation's capital, Santiago. Most commercial and administrative centers are located in the region, including Chile's main international airport, Arturo Merino Benítez International Airport.