"Talitha Cumi" is the twenty-fourth episode and the season finale of the third season of the science fiction television series The X-Files. It premiered on the Fox network on May 17, 1996, in the United States. The teleplay was written by series creator Chris Carter, based on a story he developed with lead actor David Duchovny and was directed by R. W. Goodwin. The episode is one of several that explored the series' overarching mythology. "Talitha Cumi" achieved a Nielsen household rating of 11.2, being watched by 17.86 million people in its initial broadcast. The episode received mostly positive reviews from critics.

The mythology of The X-Files, sometimes referred to as its "mytharc" by the show's staff and fans, follows the quest of FBI Special Agents Fox Mulder, a believer in supernatural phenomena, and Dana Scully, his skeptical partner. Their boss, FBI Assistant Director Walter Skinner, was also often involved. Beginning with season 8, another skeptic named John Doggett, and Monica Reyes, a believer like Mulder, were also introduced. The overarching story, which spans events as early as the 1940s, is built around a government conspiracy to hide the truth about alien existence and their doomsday plan. Not all episodes advanced the mythology plot, but those that did were often set up by Mulder or Scully via an opening monologue.