The Tallahatchie River is a river in Mississippi which flows 230 miles (370 km) from Tippah County, through Tallahatchie County, to Leflore County, where it joins the Yalobusha River to form the Yazoo River, which ultimately meets the Mississippi River at Vicksburg, Mississippi. The river is navigable for about 100 miles (160 km). At Money, Mississippi, the river's flow measures approximately 7,861 cubic feet per second.

Tippah County is a county located on the northern border of the U.S. state of Mississippi. As of the 2020 census, the population was 21,815. Its county seat is Ripley. The name "Tippah" is derived from a Chickasaw language word meaning "cut off." It was taken from the creek of the same name that flows across much of the original county from northeast to southwest before emptying into the Tallahatchie River. The creek probably was so named because it, and the ridges on either side, "cut off" the western part of the region from the eastern portion.