Talybont-on-Usk is a village and community in Powys, Wales, in the historic county of Brecknockshire. It lies on both the Caerfanell river and the Monmouthshire and Brecon Canal, about 1 mile (1.6 km) from the River Usk. In 2001, it had a population of 743, reducing to 719 at the 2011 census. The community includes the settlements of Llansantffraed, Scethrog, Aber Village, and Pencelli.

The Monmouthshire and Brecon Canal is a small network of canals in South Wales. For most of its currently (2018) navigable 35-mile (56 km) length it runs through the Brecon Beacons National Park, and its present rural character and tranquillity belies its original purpose as an industrial corridor for coal and iron, which were brought to the canal by a network of tramways and/or railroads, many of which were built and owned by the canal company.