Tando Muhammad Khan District is a district in the southern part of Sindh province in Pakistan. In north of the district, Hyderabad and Tando Allahyar districts are located; Badin district lies on south and east; and West boundary is shared with Sujawal District. The Indus River flows through Northwest. Tando Muhammad Khan district comprises the three talukas of Tando Muhammad Khan, Bulri Shah Karim and Tando Ghulam Hyder.

Tando Muhammad Khan is a city and headquarter of the Tando Muhammad Khan District located in Sindh, Pakistan. It is named after Mir Muhammad Khan Talpur Shahwani.