The Targowica Confederation was a confederation established by Polish and Lithuanian magnates on 27 April 1792, in Saint Petersburg, with the backing of the Russian Empress Catherine II. The confederation opposed the Constitution of 3 May 1791 and fought in the Polish–Russian War of 1792, which led to the Second and Third Partitions of Poland.

The 1793 Second Partition of Poland was the second of three partitions that ended the existence of the Polish–Lithuanian Commonwealth by 1795. The second partition occurred in the aftermath of the Polish–Russian War of 1792 and the Targowica Confederation of 1792, and was approved by its territorial beneficiaries, the Russian Empire and the Kingdom of Prussia. The division was ratified by the coerced Polish parliament (Sejm) in 1793 in a short-lived attempt to prevent the inevitable complete annexation of Poland, the Third Partition.