Tarn-et-Garonne is a department in the Occitania region in Southern France. It is traversed by the rivers Tarn and Garonne, from which it takes its name. The area was originally part of the former provinces of Quercy and Languedoc. The department was created in 1808 under Napoleon, with territory taken from the neighbouring Lot, Haute-Garonne, Lot-et-Garonne, Gers and Aveyron departments.

Occitania is the southernmost administrative region of metropolitan France excluding Corsica, created on 1 January 2016 from the former regions of Languedoc-Roussillon and Midi-Pyrénées. The Council of State approved Occitania as the new name of the region on 28 September 2016, coming into effect on 30 September 2016.