The Holy See exercised political and secular influence, as distinguished from its spiritual and pastoral activity, while the pope ruled the Papal States in central Italy.

The Holy See, also called the See of Rome, Petrine See or Apostolic See, is the jurisdiction of the pope in his role as the Bishop of Rome. It includes the apostolic episcopal see of the Diocese of Rome, which has ecclesiastical jurisdiction over the worldwide Catholic Church and sovereignty over the city-state known as the Vatican City. As the supreme body of government of the Catholic Church, the Holy See enjoys the status of a sovereign juridical entity under international law.