The Tenderloin is a neighborhood in downtown San Francisco, in the flatlands on the southern slope of Nob Hill, situated between the Union Square shopping district to the northeast and the Civic Center office district to the southwest. Encompassing about 50 square blocks, it is historically bounded on the north by Geary Street, on the east by Mason Street, on the south by Market Street and on the west by Van Ness Avenue. The northern boundary with Lower Nob Hill has historically been set at Geary Boulevard.

Nob Hill is a neighborhood of San Francisco, California, United States that is known for its numerous luxury hotels and historic mansions. Nob Hill has historically served as a center of San Francisco's upper class. Nob Hill is among the highest-income neighborhoods in the United States, as well as one of the most desirable and expensive real estate markets in the country. Prior to Covid-19, it was the most expensive real estate market per metre squared, narrowly beating Monte Carlo, although it has since fallen heavily. It was the only place in the United States so far where market price per square metre exceeded the average yearly salary in the country.