Tepotzotlán is a city and a municipality in the Mexican state of Mexico. It is located 40 km (25 mi) northwest of Mexico City about a 45-minute drive along the Mexico City-Querétaro at marker number 41. In Aztec times, the area was the center of a dominion that negotiated to keep most of its independence in return with being allied with the Aztec Triple Alliance. Later, it would also be part of a "Republic of the Indians," allowing for some autonomy under Spanish rule as well. The town became a major educational center during the colonial period when the Jesuits established the College of San Francisco Javier. The college complex that grew from its beginnings in 1580 would remain an educational center until 1914. Today this complex houses the Museo del Virreinato, with one of the largest collections of art and other objects from this time period.

The Museo Nacional del Virreinato is located in the former College of San Francisco Javier in Tepotzotlán, Mexico State, Mexico. It belongs to Consejo Nacional para la Cultura y las Artes. The complex was built by the Aztecs, and used by the Jesuits starting in the 1580s. Three centers of learning were founded in the complex: a school to teach indigenous languages to Jesuit evangelists, a school for native boys, and the College of San Francisco Javier, to train Jesuit priests. The complex comprises three sections: the college area, with dormitories, a library, a kitchen, and a domestic chapel; the Church of San Francisco Javier; and the Church of San Pedro Apostol. The former college and the Church of San Francisco Javier have been converted into the Museo del Virreinato, with the former college area housing a large collection of art and ordinary objects from the colonial era, and the Church of San Francisco Javier housing one of the most important collections of Churrigueresque altarpieces in Mexico. The Church of San Pedro Apostol is the only part of the entire complex that is still used for religious purposes.