The Terminal Railroad Association of St. Louis is a Class III switching and terminal railroad that handles traffic in the St. Louis metropolitan area. It is co-owned by five of the six Class I railroads that reach the city: BNSF, Canadian National, CSX, Norfolk Southern and Union Pacific. The railroad also serves Amtrak and Canadian Pacific Kansas City.

The Eads Bridge is a combined road and railway bridge over the Mississippi River connecting the cities of St. Louis, Missouri, and East St. Louis, Illinois. It is located on the St. Louis riverfront between Laclede's Landing to the north, and the grounds of the Gateway Arch to the south. The bridge is named for its designer and builder, James Buchanan Eads. Work on the bridge began in 1867, and it was completed in 1874. The Eads Bridge was the first bridge across the Mississippi south of the Missouri River. Earlier bridges were located north of the Missouri, where the Mississippi is smaller. None of the earlier bridges survive, which means that the Eads Bridge is also the oldest bridge on the river.