Seventeen days after the German invasion of Poland in 1939, which marked the beginning of the Second World War, the Soviet Union entered the eastern regions of Poland and annexed territories totalling 201,015 square kilometres (77,612 sq mi) with a population of 13,299,000. Inhabitants besides ethnic Poles included Belarusian and Ukrainian major population groups, and also Czechs, Lithuanians, Jews, and other minority groups.

Grodno Region or Hrodna Region, also known as Grodno Oblast or Hrodna Voblasts, is one of the regions of Belarus. Its administrative center, Grodno, is the largest city in the region. As of 2024, it has a population of 992,556.