Tetritskaro is a district of Georgia, in the region of Kvemo Kartli. Its main town is Tetritskaro. Tetritskaro municipality is located in the eastern part of Georgia and is a self-governing unit in the Kvemo Kartli region. The municipality is bordered on the east by Gardabani and Marneuli, on the west by Tsalka and Dmanisi, on the north by Kaspi and Mtskheta, and the south by Bolnisi. The area of the municipality is 1,175.5 km2 (453.9 sq mi), the minimum altitude is 650 metres (2,130 ft) above sea level, and the maximum altitude where the settlement is located is 1,140 metres (3,740 ft). The administrative center of the municipality - Tetritskaro - is 57 km (35 mi) away from Tbilisi, 60 km (37 mi) from the center of the region - Rustavi - and seven kilometres (4.3 mi) from the main railway (Tbilisi-Marabda-Akhalkalaki).

Kvemo Kartli or "Lower Kartli", is a historic province and current administrative region (mkhare) in southeastern Georgia. The city of Rustavi is the regional capital.