The Texas A&M–Commerce Lions football team is the college football program representing Texas A&M University–Commerce. The school competes in the Southland Conference (SLC) in Division I FCS of the National Collegiate Athletic Association (NCAA). Prior to joining the Southland, they competed in the Lone Star Conference of Division II. The A&M–Commerce football team plays its home games at Ernest Hawkins Field at Memorial Stadium on the university campus in Commerce, Texas. On Dec. 16, 2017, A&M-Commerce won its first NCAA Division II national championship, by defeating West Florida, 37-27, in Kansas City. The Lions recorded a perfect record in 1934, won the NAIA National Championship in 1972, and have amassed a total of 24 LSC conference championships since joining as a charter member in 1931. On September 28, 2021, the university accepted an invitation from the Southland Conference, moving the university's athletics programs up to the NCAA Division I level. This ended a 90-year affiliation with the Lone Star Conference, as A&M-Commerce was the last founding member remaining. The football team will compete at the NCAA Division I Football Championship Subdivision level beginning in the 2022 season.

Texas A&M University–Commerce is a public university in Commerce, Texas. With an enrollment of over 12,000 students as of fall 2017, the university is the third-largest institution in the Texas A&M University System. Founded in 1889, the institution is also the fifth-oldest state university or college in the State of Texas.