Texas County is a county located in the panhandle of the U.S. state of Oklahoma. Its county seat is Guymon. As of the 2020 census, the population was 21,384. It is the second largest county in Oklahoma, based on land area, and is named for Texas, the state that adjoins the county to its south. Texas County comprises the Guymon, OK Micropolitan Statistical Area. The county economy is largely based on farming and cattle production. It is one of the top-producing counties in the U.S. for wheat, cattle, and hogs. It also lies within the noted Hugoton-Panhandle natural gas field.

The Oklahoma Panhandle is a salient in the extreme northwestern region of the U.S. state of Oklahoma, consisting of Cimarron County, Texas County and Beaver County, from west to east. As with other salients in the United States, its name comes from the similarity of its shape to the handle of a pan. Its largest city is Guymon in Texas County. Black Mesa State Park, located in Cimarron County, is the highest point in the state. Other points of interest include Beaver Dunes Park, Optima Lake, and the Optima National Wildlife Refuge. Oklahoma Panhandle State University is ten miles away from Guymon.