State Highway 255 (SH 255) is state highway in the U.S. state of Texas that allows international traffic to bypass Laredo. Located in Webb County, the highway provides a connection between the Laredo–Colombia Solidarity International Bridge to Interstate 35 (I-35). The route opened in 2000 as the Camino Colombia Toll Road, and was one of the few operating toll roads in the United States to have gone through the legal process of foreclosure. The toll designation was removed from the route in 2017.

Webb County is a county located in the U.S. state of Texas. As of the 2020 census, its population was 267,114. Its county seat is Laredo. The county was named after James Webb (1792–1856), who served as secretary of the treasury, secretary of state, and attorney general of the Republic of Texas, and later judge of the United States District Court following the admission of Texas to statehood. By area, Webb County is the largest county in South Texas and the sixth-largest in the state. Webb County comprises the Laredo metropolitan area. Webb County is the only county in the United States to border three foreign states or provinces, sharing borders with Coahuila, Nuevo Leon, and Tamaulipas.