The $1,000,000 Chance of a Lifetime is an American game show which offered a $1 million (annuitized) grand prize to winning contestants. The show aired in syndication from January 6, 1986, until May 22, 1987. The show was hosted by Jim Lange, and he was joined by Karen Thomas as co-host during the second season. Mark Summers was the show's announcer for the first few weeks and Johnny Gilbert announced the remainder of the series. The show was produced by XPTLA, Inc., and distributed by Lorimar-Telepictures.

James John Lange was an American game show host and disc jockey. He was known to listeners in the San Francisco and Los Angeles radio markets with stints at several stations in both markets, racking up over 45 years on the air. Lange was also known to television viewers as the host of several game shows, including The Dating Game.