The Ann Sothern Show is an American sitcom starring Ann Sothern that aired on CBS for three seasons from October 6, 1958, to March 30, 1961. Created by Bob Schiller and Bob Weiskopf, the series was the second starring vehicle for Sothern, who had previously starred in Private Secretary, which also aired on CBS from 1953 to 1957.

Ann Sothern was an American actress who worked on stage, radio, film, and television, in a career that spanned nearly six decades. Sothern began her career in the late 1920s in bit parts in films. In 1930, she made her Broadway stage debut and soon worked her way up to starring roles. In 1939, MGM cast her as Maisie Ravier, a brash yet lovable Brooklyn showgirl. The character proved to be popular and spawned a successful film series and a network radio series.